Molecular rotors as conditionally fluorescent labels for rapid detection of biomolecular interactions.

Abstract

We demonstrate the use of fluorescent molecular rotors as probes for detecting biomolecular interactions, specifically peptide-protein interactions. Molecular rotors undergo twisted intramolecular charge transfer upon irradiation, relax via the nonradiative torsional relaxation pathway, and have been typically used as viscosity probes. Their utility as a… (More)
DOI: 10.1021/ja413031h

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