Molecular role of dopamine in anhedonia linked to reward deficiency syndrome (RDS) and anti- reward systems.

@article{Gold2018MolecularRO,
  title={Molecular role of dopamine in anhedonia linked to reward deficiency syndrome (RDS) and anti- reward systems.},
  author={Mark S. Gold and Kenneth Blum and Marcelo Febo and David A. Baron and Edward J. Modestino and Igor Elman and Rajendra D. Badgaiyan},
  journal={Frontiers in bioscience},
  year={2018},
  volume={10},
  pages={
          309-325
        }
}
Anhedonia is a condition that leads to the loss of feelings pleasure in response to natural reinforcers like food, sex, exercise, and social activities. This disorder occurs in addiction, and an array of related neuropsychiatric syndromes, including schizophrenia, depression, and Post Traumatic Stress Disorder (PTSD). Anhedonia may by due to derangements in mesolimbic dopaminergic pathways and their terminal fields (e.g., striatum, amygdala, and prefrontal cortex) that persist long after the… Expand
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