Molecular requirements for epithelial-mesenchymal transition during tumor progression.

  title={Molecular requirements for epithelial-mesenchymal transition during tumor progression.},
  author={Margit A Huber and Norbert Kraut and Hartmut Beug},
  journal={Current opinion in cell biology},
  volume={17 5},
Epithelial-mesenchymal transitions (EMTs) occur as key steps during embryonic morphogenesis, and are now implicated in the progression of primary tumors towards metastases. Recent advances have fostered a more detailed understanding of molecular mechanisms and networks governing EMT in tumor progression. Besides TGFbeta and RTK/Ras signaling, autocrine factors and Wnt-, Notch-, Hedgehog- and NF-kappaB-dependent pathways were found to contribute to EMT. Repression of E-cadherin by… CONTINUE READING
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