Molecular requirements for actin-based lamella formation in Drosophila S2 cells

@article{Rogers2003MolecularRF,
  title={Molecular requirements for actin-based lamella formation in Drosophila S2 cells},
  author={Stephen L. Rogers and Ursula M Wiedemann and Nico Stuurman and Ronald D Vale},
  journal={The Journal of Cell Biology},
  year={2003},
  volume={162},
  pages={1079 - 1088}
}
Cell migration occurs through the protrusion of the actin-enriched lamella. Here, we investigated the effects of RNAi depletion of approximately 90 proteins implicated in actin function on lamella formation in Drosophila S2 cells. Similar to in vitro reconstitution studies of actin-based Listeria movement, we find that lamellae formation requires a relatively small set of proteins that participate in actin nucleation (Arp2/3 and SCAR), barbed end capping (capping protein), filament… CONTINUE READING
Highly Influential
This paper has highly influenced 30 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 206 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 38 references

Similar Papers

Loading similar papers…