Molecular replacement with pseudosymmetry and model dissimilarity: a case study.

  title={Molecular replacement with pseudosymmetry and model dissimilarity: a case study.},
  author={Mariusz Jask{\'o}lski and Mi Li and Gary S. Laco and Alla Gustchina and Alexander Wlodawer},
  journal={Acta crystallographica. Section D, Biological crystallography},
  volume={62 Pt 2},
Crystals of human T-cell leukemia virus protease (HTLV-1 PR) have been very difficult to prepare and only native data extending to 2.6 angstroms resolution could be collected. Initial attempts to solve the structure with a variety of low-sequence-identity models utilizing proteases from other retroviruses and using a number of molecular-replacement programs were unsuccessful. The structure was finally solved using Phaser, revealing extensive pseudosymmetry and significant deviations from the… CONTINUE READING

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Nature (London), 337, 615–620

  • P.J.
  • Ness, S. R., de Graaff, R. A., Abrahams, J. P…
  • 1989
Highly Influential
3 Excerpts

Acta Cryst

  • W. F. Anderson
  • D59, 1138–1144. Brynda, J., Rezacova, P., Fabry…
  • 2003

Protein Sci

  • A. Wlodawer
  • 5, 1453–1465. Jones, T. A. & Kjeldgaard, M. (1997…
  • 1996


  • K. D. Watenpaugh
  • Biol. Chem. 268, 13103–13109. Murshudov, G. N…
  • 1993

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