Molecular replacement with pseudosymmetry and model dissimilarity: a case study.

@article{Jasklski2006MolecularRW,
  title={Molecular replacement with pseudosymmetry and model dissimilarity: a case study.},
  author={Mariusz Jask{\'o}lski and Mi Li and Gary S. Laco and Alla Gustchina and Alexander Wlodawer},
  journal={Acta crystallographica. Section D, Biological crystallography},
  year={2006},
  volume={62 Pt 2},
  pages={208-15}
}
Crystals of human T-cell leukemia virus protease (HTLV-1 PR) have been very difficult to prepare and only native data extending to 2.6 angstroms resolution could be collected. Initial attempts to solve the structure with a variety of low-sequence-identity models utilizing proteases from other retroviruses and using a number of molecular-replacement programs were unsuccessful. The structure was finally solved using Phaser, revealing extensive pseudosymmetry and significant deviations from the… CONTINUE READING

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