Molecular reorganization of Cx43, Zo-1 and Src complexes during the endocytosis of gap junction plaques in response to a non-genomic carcinogen.

@article{Gilleron2008MolecularRO,
  title={Molecular reorganization of Cx43, Zo-1 and Src complexes during the endocytosis of gap junction plaques in response to a non-genomic carcinogen.},
  author={J{\'e}r{\^o}me Gilleron and C{\'e}line Fiorini and D. Carette and Christiane Avondet and Matthias M Falk and Dominique Segretain and Georges Pointis},
  journal={Journal of cell science},
  year={2008},
  volume={121 Pt 24},
  pages={4069-78}
}
The gap junction protein connexin 43 (Cx43) exhibits dynamic trafficking that is altered in most tumor cells and in response to carcinogen exposure. A number of connexin (Cx)-binding proteins are known to be involved in endocytic internalization of gap junctions. Here, we analyzed the discrete molecular interactions that occur between Src, ZO-1 and Cx43 during Cx43 internalization in response to the non-genomic carcinogen gamma-hexachlorocyclohexane (HCH). Internalization of the Cx43 gap… CONTINUE READING