Molecular remodeling of Kv4.3 potassium channels in human atrial fibrillation.

@article{Grammer2000MolecularRO,
  title={Molecular remodeling of Kv4.3 potassium channels in human atrial fibrillation.},
  author={Joachim B. Grammer and Ralph F. Bosch and Volker Kuehlkamp and Ludger Seipel},
  journal={Journal of cardiovascular electrophysiology},
  year={2000},
  volume={11 6},
  pages={626-33}
}
INTRODUCTION Atrial fibrillation (AF) is associated with important alterations in cardiac ion channels that cause shortening and impaired rate adaptation of atrial repolarization. The mechanisms underlying potassium current remodeling in human AF are not clear. We investigated the effects of AF on the gene expression of the Kv4.3, Kv1.4, and Kv1.5 potassium channel subunits and correlated the findings with the transient outward (Ito) and the sustained outward (Isus or I(Kur)) potassium current… CONTINUE READING