Molecular regulation of tumour angiogenesis by nitric oxide.

  title={Molecular regulation of tumour angiogenesis by nitric oxide.},
  author={Marina Ziche and Lucia Morbidelli},
  journal={European cytokine network},
  volume={20 4},
As tumors grow, their original vasculature can be insufficient to supply the growing tissue mass, and consequently local hypoxia develops. Thus neovascularisation is a key feature determining growth and metastasis of malignant tumors. This is, at least in part, mediated by humoral factors known to stimulate angiogenesis, such as vascular endothelial growth factor (VEGF) and fibroblast growth factor-2 (FGF-2). Among the multiple angiogenic modulators released by tumor and stromal cells, a key… CONTINUE READING
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