Molecular regulation of the human IL-3 gene: inducible T cell- restricted expression requires intact AP-1 and Elf-1 nuclear protein binding sites

@article{Gottschalk1993MolecularRO,
  title={Molecular regulation of the human IL-3 gene: inducible T cell- restricted expression requires intact AP-1 and Elf-1 nuclear protein binding sites},
  author={L R Gottschalk and Diane M. Giannola and Stephen G Emerson},
  journal={The Journal of Experimental Medicine},
  year={1993},
  volume={178},
  pages={1681 - 1692}
}
Interleukin 3 (IL-3) is a hematopoietic stem-cell growth and differentiation factor that is expressed solely in activated T and NK cells. Studies to date have identified elements 5' to the IL-3 coding sequences that regulate its transcription, but the sequences that confer T cell-specific expression remain to be clearly defined. We have now identified DNA sequences that are required for T cell-restricted IL-3 gene transcription. A series of transient transfections performed with human IL-3… CONTINUE READING
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