Molecular regulation of osteoclast activity

@article{Bruzzaniti2006MolecularRO,
  title={Molecular regulation of osteoclast activity},
  author={Angela Bruzzaniti and Roland Baron},
  journal={Reviews in Endocrine and Metabolic Disorders},
  year={2006},
  volume={7},
  pages={123-139}
}
Osteoclasts are multinucleated cells derived from hematopoietic precursors that are primarily responsible for the degradation of mineralized bone during bone development, homeostasis and repair. In various skeletal disorders such as osteoporosis, hypercalcemia of malignancy, tumor metastases and Paget’s disease, bone resorption by osteoclasts exceeds bone formation by osteoblasts leading to decreased bone mass, skeletal fragility and bone fracture. The overall rate of osteoclastic bone… CONTINUE READING

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