Molecular regulation of melanocyte senescence.

  title={Molecular regulation of melanocyte senescence.},
  author={Dorothy C Bennett and Estela E. Medrano},
  journal={Pigment cell research},
  volume={15 4},
Cell senescence is the loss of ability to divide after a finite number of divisions, seen in normal mammalian somatic cells and often disrupted in cancer cells. The three genes so far associated with familial melanoma susceptibility--INK4A, CDK4 and ARF, are all implicated in the molecular pathways controlling cell senescence. Here we review those pathways, both as generally studied in fibroblasts and epithelial cells, and as specifically analysed in melanocytes. Key molecular effectors in… CONTINUE READING