Molecular regulation of genes encoding xenobiotic-metabolizing enzymes: mechanisms involving endogenous factors.

@article{Hines2001MolecularRO,
  title={Molecular regulation of genes encoding xenobiotic-metabolizing enzymes: mechanisms involving endogenous factors.},
  author={Ronald N Hines and Zejiao Luo and Thierry Cresteil and Xiaoyan Ding and Russell Allen Prough and J. Louis Souderton Fitzpatrick and Sharon L. Ripp and Keith Cameron Falkner and N L Ge and Arnold Levine and Cornelis Johan Elferink},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2001},
  volume={29 5},
  pages={
          623-33
        }
}
It is widely recognized that xenobiotic-metabolizing enzymes play a fundamental role in the basic processes of carcinogenesis and toxicity on one hand, and chemoprevention and drug efficacy on the other. Realization that different factors can profoundly affect the expression of these enzymes at the genome level has resulted in an enhanced appreciation of the importance these genes play in our modern industrialized age. There continues to be rapid proliferation of studies addressing the… CONTINUE READING

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