Molecular regulation of autophagy and its implications for metabolic diseases.

  title={Molecular regulation of autophagy and its implications for metabolic diseases.},
  author={Stefan W. Ryter and Ja Kun Koo and Augustine M. K. Choi},
  journal={Current opinion in clinical nutrition and metabolic care},
  volume={17 4},
PURPOSE OF REVIEW Autophagy is an evolutionarily conserved cellular programme for the turnover of organelles, proteins, and other macromolecules, involving the lysosomal degradation pathway. Emerging evidence suggests that autophagy can play a central role in human metabolism as well as impact diverse cellular processes including organelle homeostasis, cell death and proliferation, lipid and glycogen metabolism, and the regulation of inflammation and immune responses. The purpose of this review… CONTINUE READING

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