Molecular regulation of T-cell anergy.

  title={Molecular regulation of T-cell anergy.},
  author={Yan Zheng and Yuanyuan Zha and Thomas F Gajewski},
  journal={EMBO reports},
  volume={9 1},
The activation of T cells is tightly controlled by many positive and negative regulatory processes. This fine-tuning allows productive immunity to pathogens while minimizing the risk of autoimmunity. One negative regulatory mechanism is clonal anergy, which is a hyporesponsive state that occurs when T cells are activated through the T-cell antigen receptor in the absence of appropriate co-stimulatory signals. Recent studies have confirmed a crucial role for defective Ras activation in mediating… CONTINUE READING