Molecular regulation of DNA damage-induced apoptosis in neurons of cerebral cortex.

Abstract

Cerebral cortical neuron degeneration occurs in brain disorders manifesting throughout life, but the mechanisms are understood poorly. We used cultured embryonic mouse cortical neurons and an in vivo mouse model to study mechanisms of DNA damaged-induced apoptosis in immature and differentiated neurons. p53 drives apoptosis of immature and differentiated… (More)
DOI: 10.1093/cercor/bhn167

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