Molecular regulation--biological role of heme in hematopoiesis.

  title={Molecular regulation--biological role of heme in hematopoiesis.},
  author={Nader G Abraham},
  journal={Blood reviews},
  volume={5 1},
Heme synthesis and degradation play pivotal roles in the regulation of growth and differentiation of erythroid and non-erythroid cells. Heme synthesis in mammalian cells involves eight enzymes which are localized in mitochondrial and cytoplasmic compartments. These enzymes have been well-characterized and cDNAs for six of the enzymes has been cloned. Two enzymes in the enzymes of the heme biosynthetic pathway, delta-aminolevulinic acid synthase (ALAS) and porphobilinogen deaminase (PBG-D) have… CONTINUE READING
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