Molecular recognition. Conformational analysis of limited proteolytic sites and serine proteinase protein inhibitors.

@article{Hubbard1991MolecularRC,
  title={Molecular recognition. Conformational analysis of limited proteolytic sites and serine proteinase protein inhibitors.},
  author={Simon J. Hubbard and Stockman Campbell and Janet M. Thornton},
  journal={Journal of molecular biology},
  year={1991},
  volume={220 2},
  pages={507-30}
}
The conformations of known tryptic limited proteolytic sites have been analysed and compared to the structures of the binding regions of serine proteinase inhibitors, as they are found when complexed to a serine proteinase. Conformational parameters studied include main-chain torsion angles, root-mean-square fits, accessibility, mobility and protrusion indices. As observed before, the inhibitors share a common main-chain conformation at the binding loop from P3-P'3 (Schechter & Berger notation… CONTINUE READING
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