Molecular recognition of parathyroid hormone by its G protein-coupled receptor.

@article{Pioszak2008MolecularRO,
  title={Molecular recognition of parathyroid hormone by its G protein-coupled receptor.},
  author={Augen A Pioszak and Hongjiao Xu},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 13},
  pages={5034-9}
}
Parathyroid hormone (PTH) is central to calcium homeostasis and bone maintenance in vertebrates, and as such it has been used for treating osteoporosis. It acts primarily by binding to its receptor, PTH1R, a member of the class B G protein-coupled receptor (GPCR) family that also includes receptors for glucagon, calcitonin, and other therapeutically important peptide hormones. Despite considerable interest and much research, determining the structure of the receptor-hormone complex has been… CONTINUE READING
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