Molecular recognition of nucleic acids: coralyne binds strongly to poly(A).

@article{Xing2005MolecularRO,
  title={Molecular recognition of nucleic acids: coralyne binds strongly to poly(A).},
  author={Feifei Xing and Guangtao Song and Jinsong Ren and Jonathan B. Chaires and Xiaogang Qu},
  journal={FEBS letters},
  year={2005},
  volume={579 22},
  pages={5035-9}
}
The small molecule coralyne was found to bind preferentially and strongly to single-stranded poly(A) with an apparent association constant (Ka) of (1.8+/-0.3) x 10(6)M(-1). Binding of coralyne to poly(A) is predominantly enthalpically driven with a stoichiometry of one coralyne per four adenine bases. Poly(A) forms a coralyne dependent secondary structure with a melting temperature of 60 degrees C, for the conditions of our study. 

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