• Biology, Medicine
• Published in
  Current topics in medicinal…
  2007
• DOI:10.2174/156802607780091064

Molecular recognition of ligands in dipeptidyl peptidase IV.

@article{Kuhn2007MolecularRO,
  title={Molecular recognition of ligands in dipeptidyl peptidase IV.},
  author={Bernd Kuhn and Michael Hennig and Patrizio Mattei},
  journal={Current topics in medicinal chemistry},
  year={2007},
  volume={7 6},
  pages={
          609-19
        }
}

• Bernd Kuhn, Michael Hennig, Patrizio Mattei

The serine protease dipeptidyl peptidase IV (DPP-IV) is a clinically validated target for the treatment of type II diabetes and has received considerable interest from the pharmaceutical industry over the last years. Concomitant with a large variety of published small molecule DPP-IV inhibitors almost twenty co-crystal structures have been released to the public as of May 2006. In this review, we discuss the structural characteristics of the DPP-IV binding site and use the available X-ray… CONTINUE READING

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