Molecular recognition of ligands in dipeptidyl peptidase IV.

  title={Molecular recognition of ligands in dipeptidyl peptidase IV.},
  author={B. Kuhn and Michael Hennig and P. Mattei},
  journal={Current topics in medicinal chemistry},
  volume={7 6},
  • B. Kuhn, Michael Hennig, P. Mattei
  • Published 2007
  • Chemistry, Medicine
  • Current topics in medicinal chemistry
  • The serine protease dipeptidyl peptidase IV (DPP-IV) is a clinically validated target for the treatment of type II diabetes and has received considerable interest from the pharmaceutical industry over the last years. Concomitant with a large variety of published small molecule DPP-IV inhibitors almost twenty co-crystal structures have been released to the public as of May 2006. In this review, we discuss the structural characteristics of the DPP-IV binding site and use the available X-ray… CONTINUE READING
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