Molecular recognition of ligands in dipeptidyl peptidase IV.
@article{Kuhn2007MolecularRO, title={Molecular recognition of ligands in dipeptidyl peptidase IV.}, author={Bernd Kuhn and Michael Hennig and Patrizio Mattei}, journal={Current topics in medicinal chemistry}, year={2007}, volume={7 6}, pages={ 609-19 } }
The serine protease dipeptidyl peptidase IV (DPP-IV) is a clinically validated target for the treatment of type II diabetes and has received considerable interest from the pharmaceutical industry over the last years. Concomitant with a large variety of published small molecule DPP-IV inhibitors almost twenty co-crystal structures have been released to the public as of May 2006. In this review, we discuss the structural characteristics of the DPP-IV binding site and use the available X-ray… CONTINUE READING
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