Molecular recognition of ligands in dipeptidyl peptidase IV.

@article{Kuhn2007MolecularRO,
  title={Molecular recognition of ligands in dipeptidyl peptidase IV.},
  author={B. Kuhn and Michael Hennig and P. Mattei},
  journal={Current topics in medicinal chemistry},
  year={2007},
  volume={7 6},
  pages={
          609-19
        }
}
  • B. Kuhn, Michael Hennig, P. Mattei
  • Published 2007
  • Chemistry, Medicine
  • Current topics in medicinal chemistry
    • The serine protease dipeptidyl peptidase IV (DPP-IV) is a clinically validated target for the treatment of type II diabetes and has received considerable interest from the pharmaceutical industry over the last years. Concomitant with a large variety of published small molecule DPP-IV inhibitors almost twenty co-crystal structures have been released to the public as of May 2006. In this review, we discuss the structural characteristics of the DPP-IV binding site and use the available X-ray… CONTINUE READING
    View on PubMed
    doi.org
    57 Citations
    Highly Influencial Citations
    1
    Background Citations
    8
    Results Citations
    1
    57 Citations
    Citation Type

    Citation Type

    Dipeptidyl peptidase IV and its inhibitors: therapeutics for type 2 diabetes and what else?
    • 106
    Computational studies on structurally diverse dipeptidyl peptidase IV inhibitors: an approach for new antidiabetic drug development
    • 8
    Novel aspects of cellular action of dipeptidyl peptidase IV/CD26
    • 40
    Identification of Novel Human Dipeptidyl Peptidase-IV Inhibitors of Natural Origin (Part I): Virtual Screening and Activity Assays
    • 35
    • Highly Influenced
    • PDF
    Inhibition of dipeptidyl peptidase IV (DPP IV) is one of the mechanisms explaining the hypoglycemic effect of berberine
    • 94
    3D-QSAR studies of dipeptidyl peptidase-4 inhibitors using various alignment methods
    • 11
    Molecular Docking Interaction of Pinitol (Ligand) with Dipeptidyl Peptidase-4 Receptor (PDB 3C45)
    • 1
    • PDF
    Recent approaches to medicinal chemistry and therapeutic potential of dipeptidyl peptidase-4 (DPP-4) inhibitors.
    • 58
    QSAR study of dipeptidyl peptidase-4 inhibitors based on the Monte Carlo method
    • 13
    Activity and selectivity cliffs for DPP‐IV inhibitors: Lessons we can learn from SAR studies and their application to virtual screening
    • 8