Molecular recognition of a single sphingolipid species by a protein’s transmembrane domain

@article{Contreras2012MolecularRO,
  title={Molecular recognition of a single sphingolipid species by a protein’s transmembrane domain},
  author={F.-Xabier Contreras and Andreas Ernst and Per Haberkant and Patrik Bj{\"o}rkholm and Erik Lindahl and Başak G{\"o}nen and Christian Tischer and Arne Elofsson and Gunnar von Heijne and Christoph Thiele and Rainer Pepperkok and Felix Wieland and Britta Bruegger},
  journal={Nature},
  year={2012},
  volume={481},
  pages={525-529}
}
Functioning and processing of membrane proteins critically depend on the way their transmembrane segments are embedded in the membrane. Sphingolipids are structural components of membranes and can also act as intracellular second messengers. Not much is known of sphingolipids binding to transmembrane domains (TMDs) of proteins within the hydrophobic bilayer, and how this could affect protein function. Here we show a direct and highly specific interaction of exclusively one sphingomyelin species… CONTINUE READING
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