Molecular recognition in purinergic receptors. 2. Diastereoselectivity of the h-P2Y1-receptor.

@article{Major2004MolecularRI,
  title={Molecular recognition in purinergic receptors. 2. Diastereoselectivity of the h-P2Y1-receptor.},
  author={Dan Thomas Major and Victoria Nahum and Yingfei Wang and Georg Reiser and Bilha Fischer},
  journal={Journal of medicinal chemistry},
  year={2004},
  volume={47 18},
  pages={4405-16}
}
In the companion paper, part 1, we described the construction of an improved molecular model for the h-P2Y1 receptor (h-P2Y1-R) and proposed a rational for the stereoelectronic selectivity of the receptor. Here, we extend our studies on the molecular recognition of the h-P2Y1-R to the exploration of the diastereoselectivity of this receptor. For this purpose, we implemented an integrative approach combining synthesis, spectral analysis, biochemical assays, and computational analysis… CONTINUE READING
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