Molecular recognition and targeting of lysosomal proteins.

@article{Figura1991MolecularRA,
  title={Molecular recognition and targeting of lysosomal proteins.},
  author={Kurt von Figura},
  journal={Current opinion in cell biology},
  year={1991},
  volume={3 4},
  pages={
          642-6
        }
}
Recent studies have established that in mammalian cells insulin-like growth factor-II can couple the large mannose-6-phosphate receptor to a GTP-binding protein and that the insulin-like growth factor-II-induced activation of the GTP-binding protein is inhibited by mannose-6-phosphate and lysosomal enzymes. In mouse, the gene for the large mannose-6-phosphate receptor is maternally imprinted. 

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