Molecular properties of epithelial, amiloride-blockable Na+ channels.

  title={Molecular properties of epithelial, amiloride-blockable Na+ channels.},
  author={Haim Garty},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={8 8},
  • Haim Garty
  • Published 1994 in
    FASEB journal : official publication of the…
The apical membrane of many tight epithelia contains Na+ channels that are primarily characterized by their high affinity to the diuretic blocker amiloride. These channels mediate the first step of active Na+ reabsorption essential for the maintenance of body salt and water homeostasis. They are regulated by mineralocorticoids, antidiuretic peptides, atrial natriuretic peptides, and other factors. The molecular events that mediate the hormonal actions are poorly understood. In addition, patch… CONTINUE READING


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Amioride - sensitive epithelial sodium channel is made of three homologous subunits

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