Molecular properties of amphotericin B membrane channel: a molecular dynamics simulation.

Abstract

Amphotericin B is a powerful but toxic antifungal antibiotic that is used to treat systemic infections. It forms ionic membrane channels in fungal cells. These antibiotic/sterol channels are responsible for the leakage of ions, which causes cell destruction. The detailed molecular properties and structure of amphotericin B channels are still unknown. In the… (More)

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Cite this paper

@article{Baginski1997MolecularPO, title={Molecular properties of amphotericin B membrane channel: a molecular dynamics simulation.}, author={Maciej Baginski and Haluk Resat and J. A. McCammon}, journal={Molecular pharmacology}, year={1997}, volume={52 4}, pages={560-70} }