Molecular properties and CYP2D6 substrates: central nervous system therapeutics case study and pattern analysis of a substrate database.

@article{Chico2009MolecularPA,
  title={Molecular properties and CYP2D6 substrates: central nervous system therapeutics case study and pattern analysis of a substrate database.},
  author={Laura K. Chico and Heather A Behanna and Wenhui Hu and Guifa Zhong and Saktimayee Mitra Roy and D Martin Watterson},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2009},
  volume={37 11},
  pages={2204-11}
}
CYP2D6 substrate status is a critical Go/No Go decision criteria in central nervous system (CNS) drug discovery efforts because the polymorphic nature of CYP2D6 can lead to variable patient safety and drug efficacy. In addition, CYP2D6 is disproportionately involved in the metabolism of CNS drugs compared with other drug classes. Therefore, identifying trends in small molecule properties of CNS-penetrant compounds that can help discriminate potential CYP2D6 substrates from nonsubstrates would… CONTINUE READING
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