Molecular profiling uncovers a p53-associated role for microRNA-31 in inhibiting the proliferation of serous ovarian carcinomas and other cancers.

@article{Creighton2010MolecularPU,
  title={Molecular profiling uncovers a p53-associated role for microRNA-31 in inhibiting the proliferation of serous ovarian carcinomas and other cancers.},
  author={Chad J Creighton and Michael D. Fountain and Zhifeng Yu and Ankur K. Nagaraja and Huifeng Zhu and Mahjabeen Khan and Emuejevoke Olokpa and Azam Zariff and Preethi H. Gunaratne and Martin M. Matzuk and Matthew L Anderson},
  journal={Cancer research},
  year={2010},
  volume={70 5},
  pages={
          1906-15
        }
}
MicroRNAs (miRNA) regulate complex patterns of gene expression, and the relevance of altered miRNA expression to ovarian cancer remains to be elucidated. By comprehensively profiling expression of miRNAs and mRNAs in serous ovarian tumors and cell lines and normal ovarian surface epithelium, we identified hundreds of potential miRNA-mRNA targeting associations underlying cancer. Functional overexpression of miR-31, the most underexpressed miRNA in serous ovarian cancer, repressed predicted miR… CONTINUE READING

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