Molecular profiling reveals prognostically significant subtypes of canine lymphoma.

  title={Molecular profiling reveals prognostically significant subtypes of canine lymphoma.},
  author={Aric M. Frantz and Aaron L. Sarver and Daisuke Ito and Tzu L. Phang and Anis Karimpour-Fard and M Cathy Scott and Victor E. O. Valli and Kerstin Lindblad-Toh and Kristine E Burgess and Brian D Husbands and Michael S. Henson and Antonella Borgatti and William C. Kisseberth and Lawrence E. Hunter and Matthew Breen and Timothy O'Brien and Jaime F Modiano},
  journal={Veterinary pathology},
  volume={50 4},
We performed genomewide gene expression analysis of 35 samples representing 6 common histologic subtypes of canine lymphoma and bioinformatics analyses to define their molecular characteristics. Three major groups were defined on the basis of gene expression profiles: (1) low-grade T-cell lymphoma, composed entirely by T-zone lymphoma; (2) high-grade T-cell lymphoma, consisting of lymphoblastic T-cell lymphoma and peripheral T-cell lymphoma not otherwise specified; and (3) B-cell lymphoma… CONTINUE READING
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