Molecular profiling reveals a tumor-promoting phenotype of monocytes and macrophages in human cancer progression.

@article{Chittezhath2014MolecularPR,
  title={Molecular profiling reveals a tumor-promoting phenotype of monocytes and macrophages in human cancer progression.},
  author={Manesh Chittezhath and Manprit Kaur Dhillon and Jyue Yuan Lim and Damya Laoui and Irina N. Shalova and Yi Ling Teo and Jinmiao Chen and Revathy Kamaraj and Lata Raman and Josephine Lum and Thomas Paulraj Thamboo and Edmund Chiong and Francesca Zolezzi and Henry Yang and Jo A. van Ginderachter and Michael Poidinger and Alvin Seng Cheong Wong and Subhra K. Biswas},
  journal={Immunity},
  year={2014},
  volume={41 5},
  pages={815-29}
}
Monocytes and macrophages are major components of the tumor microenvironment, but their contributions to human cancer are poorly understood. We used molecular profiling combined with functional assays to investigate the role of these cells in human renal cell carcinoma (RCC). Blood monocytes from RCC patients displayed a tumor-promoting transcriptional profile that supported functions like angiogenesis and invasion. Induction of this protumor phenotype required an interleukin-1 receptor (IL-1R… CONTINUE READING
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