Molecular profiling of patient-matched brain and extracranial melanoma metastases implicates the PI3K pathway as a therapeutic target.

@article{Chen2014MolecularPO,
  title={Molecular profiling of patient-matched brain and extracranial melanoma metastases implicates the PI3K pathway as a therapeutic target.},
  author={G. Chen and Nitin Chakravarti and Kim Aardalen and A. J. Lazar and M. T. Tetzlaff and Bradley Wubbenhorst and S-W. Kim and Scott Kopetz and A. A. Ledoux and Y. N. V. Gopal and C. G. Pereira and Weilun Deng and J.-S. Lee and K. L. Nathanson and K. D. Aldape and V. G. Prieto and Dent Stuart and M. A. Davies},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2014},
  volume={20 21},
  pages={
          5537-46
        }
}
PURPOSE An improved understanding of the molecular pathogenesis of brain metastases, one of the most common and devastating complications of advanced melanoma, may identify and prioritize rational therapeutic approaches for this disease. In particular, the identification of molecular differences between brain and extracranial metastases would support the need for the development of organ-specific therapeutic approaches. EXPERIMENTAL DESIGN Hotspot mutations, copy number variations (CNV… CONTINUE READING

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