Molecular profiling of bladder tumors based on the detection of FGFR3 and TP53 mutations.

@article{Lamy2006MolecularPO,
  title={Molecular profiling of bladder tumors based on the detection of FGFR3 and TP53 mutations.},
  author={Aude Lamy and Françoise Gobet and Marie Laurent and France Blanchard and Christophe Varin and Camilo Moulin and Avgi Andreou and Thierry 11 Fr{\'e}bourg and Christian Pfister},
  journal={The Journal of urology},
  year={2006},
  volume={176 6 Pt 1},
  pages={2686-9}
}
PURPOSE On a routine basis we performed systematic molecular screening for FGFR3 and TP53 mutations in 121 bladder tumors. We then specifically analyzed the predictive value of the recurrence of FGFR3 and TP53 genotypes in superficial lesions. MATERIALS AND METHODS The FGFR3 gene was analyzed by direct sequencing of exons 7, 10 and 15, whereas TP53 status was determined using the p53 functional assay in yeast. RESULTS We identified a missense FGFR3 mutation in 66% of pTa, 26% of pT1 and 12… CONTINUE READING