Molecular profiling of advanced solid tumors and patient outcomes with genotype-matched clinical trials: the Princess Margaret IMPACT/COMPACT trial

@inproceedings{Stockley2016MolecularPO,
  title={Molecular profiling of advanced solid tumors and patient outcomes with genotype-matched clinical trials: the Princess Margaret IMPACT/COMPACT trial},
  author={Tracy L. Stockley and Amit M Oza and Hal K. Berman and Natasha B Leighl and Jennifer J. Knox and Frances A. Shepherd and Eric XH Chen and Monika K Krzyzanowska and Neesha Dhani and Anthony Michael Joshua and M S Tsao and Stefano Serra and Blaise Alexander Clarke and Michael H.A. Roehrl and Tong Zhang and Mahadeo A Sukhai and Nadia Califaretti and Mateya Trinkaus and Patricia A. Shaw and Theodorus van der Kwast and Lisa Wang and Carl Virtanen and Raymond H. Kim and Albiruni R A Razak and Aaron R Hansen and Celeste Yu and Trevor J Pugh and Suzanne Kamel-Reid and Lillian L Siu and Philippe L B{\'e}dard},
  booktitle={Genome Medicine},
  year={2016}
}
The clinical utility of molecular profiling of tumor tissue to guide treatment of patients with advanced solid tumors is unknown. Our objectives were to evaluate the frequency of genomic alterations, clinical “actionability” of somatic variants, enrollment in mutation-targeted or other clinical trials, and outcome of molecular profiling for advanced solid tumor patients at the Princess Margaret Cancer Centre (PM). Patients with advanced solid tumors aged ≥18 years, good performance status, and… CONTINUE READING
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