Molecular profiles of Quadriceps muscle in myostatin-null mice reveal PI3K and apoptotic pathways as myostatin targets

@article{Chelh2008MolecularPO,
  title={Molecular profiles of Quadriceps muscle in myostatin-null mice reveal PI3K and apoptotic pathways as myostatin targets},
  author={Ilham Chelh and Bruno Meunier and Brigitte Picard and Mark James Reecy and Catherine Chevalier and Jean-françois Hocquette and Isabelle Cassar-Malek},
  journal={BMC Genomics},
  year={2008},
  volume={10},
  pages={196 - 196}
}
Myostatin (MSTN), a member of the TGF-β superfamily, has been identified as a negative regulator of skeletal muscle mass. Inactivating mutations in the MSTN gene are responsible for the development of a hypermuscular phenotype. In this study, we performed transcriptomic and proteomic analyses to detect altered expression/abundance of genes and proteins. These differentially expressed genes and proteins may represent new molecular targets of MSTN and could be involved in the regulation of… CONTINUE READING
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A Mutation in the Myostatin Gene Increases Muscle Mass and Enhances Racing Performance in Heterozygote Dogs

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