Molecular profile of an antibody response to HIV-1 as probed by combinatorial libraries.

@article{Barbas1993MolecularPO,
  title={Molecular profile of an antibody response to HIV-1 as probed by combinatorial libraries.},
  author={Carlos F. Barbas and Tha´ıs Collet and Willi Amberg and P W Roben and James M Binley and Dick Hoekstra and D Cababa and Terry M Jones and Robert Anthony Williamson and G R Pilkington},
  journal={Journal of molecular biology},
  year={1993},
  volume={230 3},
  pages={812-23}
}
A large number (33) of human Fab fragments reacting with HIV-1 surface glycoprotein gp120 have been generated by selection from a combinatorial IgG1 kappa library displayed on the surface of phage. The library was prepared from a long term asymptomatic HIV-seropositive donor. Analysis of the sequences from these Fabs shows the heavy chains can be placed in groups, many of which contain intraclonal variants, almost certainly corresponding to chains used in vivo. Further variants can be accessed… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 23 extracted citations

Crystal structure of a 3B3 variant--a broadly neutralizing HIV-1 scFv antibody.

Protein science : a publication of the Protein Society • 2009
View 5 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…