Corpus ID: 12835506

Molecular probing of the secretory pathway in peptide hormone-producing cells.

@article{Holthuis1995MolecularPO,
  title={Molecular probing of the secretory pathway in peptide hormone-producing cells.},
  author={Joost C M Holthuis and Eric J. R. Jansen and M. C. van Riel and G. J. Martens},
  journal={Journal of cell science},
  year={1995},
  volume={108 ( Pt 10)},
  pages={
          3295-305
        }
}
  • Joost C M Holthuis, Eric J. R. Jansen, +1 author G. J. Martens
  • Published in Journal of cell science 1995
  • Biology, Chemistry, Medicine
  • The biosynthetic machinery in the melanotrope cells of the Xenopus intermediate pituitary is primarily dedicated to the generation of proopiomelanocortin (POMC)-derived, melanophore-stimulating peptides. Transfer of the animal to a black background stimulates the production of these peptides and causes a dramatic increase in POMC mRNA levels. To identify genes involved in the biosynthesis and regulated release of peptide hormones, we differentially screened an intermediate pituitary cDNA… CONTINUE READING

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