Molecular principles of cancer invasion and metastasis (review).

@article{Leber2009MolecularPO,
  title={Molecular principles of cancer invasion and metastasis (review).},
  author={Mathias Felix Leber and Thomas H Efferth},
  journal={International journal of oncology},
  year={2009},
  volume={34 4},
  pages={
          881-95
        }
}
The main threat and the reason for most cancer deaths are not the primary neoplasias, but secondary tumors, the metastases. Drastic phenotypic and biochemical changes occur during the metamorphosis of a normal tissue cell into an invasive cancer cell. These alterations concern various areas such as growth factor signaling, cell-cell adhesion, gene expression, motility or cell shape. Cancer cells of epithelial origin can even shed their typical qualities and characteristics and adopt a… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 96 CITATIONS, ESTIMATED 49% COVERAGE

212 Citations

0102030'10'12'14'16'18
Citations per Year
Semantic Scholar estimates that this publication has 212 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
SHOWING 1-10 OF 75 REFERENCES

Cancer stem cells : the centrality of translational research to cancer control

  • A Bernstein
  • CMAJ
  • 2007

Similar Papers

Loading similar papers…