Molecular portraits and 70-gene prognosis signature are preserved throughout the metastatic process of breast cancer.

Abstract

Microarray analysis has been shown to improve risk stratification of breast cancer. Breast tumors analyzed by hierarchical clustering of expression patterns of "intrinsic" genes have been reported to subdivide into at least four molecular subtypes that are associated with distinct patient outcomes. Using a supervised method, a 70-gene expression profile has… (More)

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