Molecular physiology and genetics of Na+-independent SLC4 anion exchangers.

  title={Molecular physiology and genetics of Na+-independent SLC4 anion exchangers.},
  author={Seth L Alper},
  journal={The Journal of experimental biology},
  volume={212 Pt 11},
Plasmalemmal Cl(-)/HCO(3)(-) exchangers are encoded by the SLC4 and SLC26 gene superfamilies, and function to regulate intracellular pH, [Cl(-)] and cell volume. The Cl(-)/HCO(3)(-) exchangers of polarized epithelial cells also contribute to transepithelial secretion and reabsorption of acid-base equivalents and Cl(-). This review focuses on Na(+)-independent electroneutral Cl(-)/HCO(3)(-) exchangers of the SLC4 family. Human SLC4A1/AE1 mutations cause the familial erythroid disorders of… CONTINUE READING
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