Molecular phylogenetics before sequences: oligonucleotide catalogs as k-mer spectra.


From 1971 to 1985, Carl Woese and colleagues generated oligonucleotide catalogs of 16S/18S rRNAs from more than 400 organisms. Using these incomplete and imperfect data, Carl and his colleagues developed unprecedented insights into the structure, function, and evolution of the large RNA components of the translational apparatus. They recognized a third… (More)
DOI: 10.4161/rna.27505


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