Molecular photoacoustic imaging of angiogenesis with integrin-targeted gold nanobeacons.

  title={Molecular photoacoustic imaging of angiogenesis with integrin-targeted gold nanobeacons.},
  author={Dipanjan Pan and Manojit Pramanik and Angana Senpan and John S. Allen and Huiying Zhang and Samuel A. Wickline and Lihong V. Wang and Gregory M. Lanza},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={25 3},
Photoacoustic tomography (PAT) combines optical and acoustic imaging to generate high-resolution images of microvasculature. Inherent sensitivity to hemoglobin permits PAT to image blood vessels but precludes discriminating neovascular from maturing microvasculature. α(v)β(3)-Gold nanobeacons (α(v)β(3)-GNBs) for neovascular molecular PAT were developed, characterized, and demonstrated in vivo using a mouse Matrigel-plug model of angiogenesis. PAT results were microscopically corroborated with… CONTINUE READING


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