Molecular phenotype of spontaneously arising 4N (G2-tetraploid) intermediates of neoplastic progression in Barrett's esophagus.

@article{Barrett2003MolecularPO,
  title={Molecular phenotype of spontaneously arising 4N (G2-tetraploid) intermediates of neoplastic progression in Barrett's esophagus.},
  author={Michael T. Barrett and David Pritchard and Corinna Palanca-Wessels and Judy D Anderson and Brian J. Reid and Peter S. Rabinovitch},
  journal={Cancer research},
  year={2003},
  volume={63 14},
  pages={4211-7}
}
Elevated 4N (G(2)-tetraploid) cell populations are unstable intermediates in the development of many human cancers. However, 4N cell populations are intermixed with larger diploid fractions in vivo, limiting investigation of these key intermediates of neoplastic progression. Therefore, to study elevated 4N cell populations in human neoplasia, we used flow cytometry to purify populations of spontaneously arising TP53(wt) and TP53(mut) 4N cells from cell strains derived from premalignant Barrett… CONTINUE READING
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