Molecular pharmacology of the interaction of anthracyclines with iron.

@article{Xu2005MolecularPO,
  title={Molecular pharmacology of the interaction of anthracyclines with iron.},
  author={Xu K Xu and H L Persson and Des. R. Richardson},
  journal={Molecular pharmacology},
  year={2005},
  volume={68 2},
  pages={261-71}
}
Although anthracyclines such as doxorubicin are widely used antitumor agents, a major limitation for their use is the development of cardiomyopathy at high cumulative doses. This severe adverse side effect may be due to interactions with cellular iron metabolism, because iron loading promotes anthracycline-induced cell damage. On the other hand, anthracycline-induced cardiotoxicity is significantly alleviated by iron chelators (e.g., desferrioxamine and dexrazoxane). The molecular mechanisms by… CONTINUE READING

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