Molecular pharmacology of somatostatin receptors

  title={Molecular pharmacology of somatostatin receptors},
  author={Daniel Hoyer and Hermann Luebbert and Christian Bruns},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
The neuropeptide somatostatin (SRIF) is widely expressed in the brain and in the periphery in two main forms, SRIF-14 and SRIF-28. Similarly, the presence of SRIF receptors throughout the whole body has been reported. SRIF produces a variety of effects including modulation of hormone release (e.g. GH, glucagon, insulin), of neurotransmitter release (e.g. acetylcholine, dopamine, 5-HT), and its own release is modulated by many neurotransmitters. SRIF affects cognitive and behavioural processes… CONTINUE READING


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Publications referenced by this paper.
Showing 1-10 of 151 references

Coexpression of somatostatin SSTR-4 and SSTR-3 receptor mRNAs in the rat central nervous sytem

J Perez, D Hoyer
View 1 Excerpt

Pharmacological identity between somatostatin SS-1/SS-2 sites and SSTR-2/SSTR-I receptors

D Hoyer, P Schoeffter, +4 authors C Bruns
respectively. Neuropeptides • 1994

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