Molecular pharmacology of cocaine: a dopamine hypothesis and its implications.

@article{Kuhar1992MolecularPO,
  title={Molecular pharmacology of cocaine: a dopamine hypothesis and its implications.},
  author={Michael Kuhar},
  journal={Ciba Foundation symposium},
  year={1992},
  volume={166},
  pages={81-9; discussion 89-95}
}
The reinforcing properties of cocaine have been related to cocaine binding at the dopamine transporter in mesolimbocortical neurons. The molecular properties of the transporter have been studied in a number of laboratories. While this 'dopamine hypothesis' is strongly supported in animal studies of drug self-administration, the extent of its involvement in human drug dependence has not been fully elucidated.