Molecular pharmacology of adenosine transport in Trypanosoma brucei: P1/P2 revisited.

@article{Geiser2005MolecularPO,
  title={Molecular pharmacology of adenosine transport in Trypanosoma brucei: P1/P2 revisited.},
  author={Federico Geiser and Alexandra L{\"u}scher and Harry P de Koning and Thomas Johann Seebeck and Pascal M{\"a}ser},
  journal={Molecular pharmacology},
  year={2005},
  volume={68 3},
  pages={
          589-95
        }
}
Trypanosoma brucei are unicellular parasites that cause sleeping sickness in humans and nagana in livestock. Trypanosomes salvage purines from their hosts through a variety of transporters, of which adenosine permeases deserve particular attention because of their role in drug sensitivity. T. brucei possess two distinct adenosine transport systems, P1 and P2, the latter of which also mediates cellular uptake of the drugs melarsoprol and pentamidine. Loss or mutation of P2 has been associated… CONTINUE READING

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