Molecular pharmacology of 5-HT1 and 5-HT2 recognition sites in rat and pig brain membranes: radioligand binding studies with [3H]5-HT, [3H]8-OH-DPAT, (-)[125I]iodocyanopindolol, [3H]mesulergine and [3H]ketanserin.

@article{Hoyer1985MolecularPO,
  title={Molecular pharmacology of 5-HT1 and 5-HT2 recognition sites in rat and pig brain membranes: radioligand binding studies with [3H]5-HT, [3H]8-OH-DPAT, (-)[125I]iodocyanopindolol, [3H]mesulergine and [3H]ketanserin.},
  author={Daniel Hoyer and G{\"u}nther Engel and Hans Otto Kalkman},
  journal={European journal of pharmacology},
  year={1985},
  volume={118 1-2},
  pages={
          13-23
        }
}
Identity of inhibitory presynaptic 5-hydroxytryptamine (5-HT) autoreceptors in the rat brain cortex with 5-HT1B binding sites
TLDR
In rat brain cortex slices preincubated with [3H]5-HT, the evidence indicates that the presynaptic 5- HT autoreceptor belongs to the 5-HT1B receptor subtype.
“5-HT1R” or 5-HT1D sites? Evidence for 5-HT 1D binding sites in rabbit brain
TLDR
The present data strongly suggest that rabbit brain has recognition sites with the pharmacological profile and distribution characteristic of the 5-HT1D recognition site and are in agreement with results obtained by Limberger et al. (1991).
5-HT1D receptors in guinea-pig and pigeon brain
TLDR
It is suggested that 5-HT1D sites may be present in the brain of the majority of vertebrate species located higher than the sauropside-mammalian divergence in the phylogenic tree, whereas 5- HT1B sites are only found in some rodents.
Chronic effects of imipramine and lithium on 5-HT receptor subtypes in rat frontal cortex, hippocampus and choroid plexus: quantitative receptor autoradiographic analysis.
TLDR
It is proposed that methods employing quantitative receptor autoradiographic analysis can be used to characterize and understand the local effects of these drugs on 5-HT receptor subtypes.
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References

SHOWING 1-10 OF 28 REFERENCES
Multiple serotonin receptors: differential binding of [3H]5-hydroxytryptamine, [3H]lysergic acid diethylamide and [3H]spiroperidol.
TLDR
It is proposed that [3H]5-HT and[3H]-spiroperidol label distinct populations of serotonin receptors in rat brain, designated 5-HT1 and 5- HT2 receptors, respectively.
8-Hydroxy-2-(di-n-propylamino) tetralin is devoid of activity at the 5-hydroxytryptamine autoreceptor in rat brain. Implications for the proposed link between the autoreceptor and the [3H] 5-HT recognition site
  • D. Middlemiss
  • Biology
    Naunyn-Schmiedeberg's Archives of Pharmacology
  • 2004
TLDR
Experiments have failed to provide direct evidence for agonist activity of 8-OH-DPAT at the 5-HT autoreceptor and alternative explanations must be sought for its biochemical and behavioural effects in vivo.
Determination of selective and nonselective compounds for the 5-HT 1A and 5-HT 1B receptor subtypes in rat frontal cortex.
TLDR
The ability of a series of drugs to compete for 15 nM [3H]-5-HT binding in the presence of 1 mM GTP in the rat frontal cortex was examined to examine the ability of these drugs to selectivity for two subtypes of the 5-HT1 receptor.
Identification of presynaptic serotonin autoreceptors using a new ligand: 3H-PAT
TLDR
3H-PAT seems to be a useful ligand for studying the biochemical and pharmacological characteristics of presynaptic autoreceptors in selected regions of rat brain.
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