Molecular pharmacology and antitumor activity of Zalypsis in several human cancer cell lines.

@article{Leal2009MolecularPA,
  title={Molecular pharmacology and antitumor activity of Zalypsis in several human cancer cell lines.},
  author={J. Leal and V. Garc{\'i}a-Hern{\'a}ndez and V. Moneo and A. Domingo and J. Bueren-Calabuig and A. Negri and F. Gago and M. J. Guill{\'e}n-Navarro and P. Avil{\'e}s and C. Cuevas and L. Garc{\'i}a-Fern{\'a}ndez and C. Galmarini},
  journal={Biochemical pharmacology},
  year={2009},
  volume={78 2},
  pages={
          162-70
        }
}
Zalypsis is a new synthetic alkaloid tetrahydroisoquinoline antibiotic that has a reactive carbinolamine group. This functionality can lead to the formation of a covalent bond with the amino group of selected guanines in the DNA double helix, both in the absence and in the presence of methylated cytosines. The resulting complex is additionally stabilized by the establishment of one or more hydrogen bonds with adjacent nucleotides in the opposite strand as well as by van der Waals interactions… Expand
PM00104 (Zalypsis®): A Marine Derived Alkylating Agent
Levels of active tyrosine kinase receptor determine the tumor response to Zalypsis
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