Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis

  title={Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis},
  author={Laura Ferraiuolo and J. Kirby and A. Grierson and M. Sendtner and P. Shaw},
  journal={Nature Reviews Neurology},
  • Laura Ferraiuolo, J. Kirby, +2 authors P. Shaw
  • Published 2011
  • Biology, Medicine
  • Nature Reviews Neurology
  • Amyotrophic lateral sclerosis (ALS) is a genetically diverse disease. At least 15 ALS-associated gene loci have so far been identified, and the causative gene is known in approximately 30% of familial ALS cases. Less is known about the factors underlying the sporadic form of the disease. The molecular mechanisms of motor neuron degeneration are best understood in the subtype of disease caused by mutations in superoxide dismutase 1, with a current consensus that motor neuron injury is caused by… CONTINUE READING
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