Molecular pathways of anxiety revealed by knockout mice

  title={Molecular pathways of anxiety revealed by knockout mice},
  author={Sarah J. Wood and Mikl{\'o}s T{\'o}th},
  journal={Molecular Neurobiology},
Anxiety is a normal reaction to threatening situations, and serves a physiological protective function. Pathological anxiety is characterized by a bias to interpret ambiguous situations as threatening, by avoidance of situations that are perceived to be harmful, and/or by exaggerated reactions to threat. Although much evidence indicates the involvement of the γ-aminobutyric acid, serotonin, norepinephrine, dopamine, and neuropeptide transmitter systems in the pathophysiology of anxiety, little… CONTINUE READING