Molecular pathways of aging and hypertension.

  title={Molecular pathways of aging and hypertension.},
  author={Giovanni G Camici and Isabella Sudano and Georg Noll and Felix C. Tanner and Thomas Felix L{\"u}scher},
  journal={Current opinion in nephrology and hypertension},
  volume={18 2},
PURPOSE OF REVIEW This review is aimed at describing the latest advances made in understanding the pathogenesis of vascular aging and hypertension and their underlying molecular mechanisms. RECENT FINDINGS p66shc and endothelin-1 are highly implicated in vascular aging and hypertension, respectively. Increased production of reactive oxygen species observed in aging and hypertension may provide the missing link interconnecting endothelin-1 and p66shc. Through several studies performed in… CONTINUE READING

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